Okay. So, there are 3 main estradiol level simulators that we find useful for different reasons.
Trans Fem Science.Estrannaise.Grey Oasis
Trans Fem Science's one is the OG. It's fairly simple to use, but lacks the features available in others.
We used to find that it vastly overestimated levels, but we've recently-ish discovered that many different things can raise estradiol sensitivity overall, or your level on a blood test on a given day, so we're more forgiving of it now.
Estrannaise is more advanced, and fairly simple (ish) to use, once you've got the hang out of it. It's particularly helpful for calculating ramping up and/or switching from one ester to another.
However, its level estimations for undecylate are very low and seemingly very out of touch with other simulators, making it difficult to recommend for calculating ramping up or determining doses.
Grey Oasis is based off the Trans Fem Science simulator, but gives you the ability to calculate ramping up or switching esters, albeit in a non-user-friendly way. It also looks like the creator hasn't touched their website for a couple of years, so there's always a chance it may just disappear one day.
If you want to simulate a switchover from one ester to undecylate on Grey Oasis, we recommend getting it to simulate a ramp up on your current ester, followed by the same on the other.
For example, this will simulate a switchover from EEn (4 mg weekly) to EUn (12 mg fortnightly):
0/6/EEn, 7/4/EEn, 14/4/EEn, 21/4/EEn, 28/4/EEn, 35/4/EEn, 42/12/EUn, 49/12/EUn, 56/12/EUn, 70/12/EUn, 84/12/EUn, 98/12/EUn, 112/12/EUn, 126/12/EUn, 140/12/EUn, 154/12/EUn, 168/12/EUn, 182/12/EUn, 196/12/EUn, 210/12/EUn, 224/12/EUn, 238/12/EUn, 252/12/EUn, 266/12/EUn, 280/12/EUn
The same entries give a vastly-different simulated result in Estrannaise. (We've added the stable dose line for comparison.)
From what we've been advised from others within the homebrew community who have more experience with EUn, there are a couple of big reasons for discrepancies:
There's not much underlying data for EUn, and the data available is old.The carrier oil has a major impact with EUn, changing the effective elimination half-life (t=½).~21 days in MCT oil.~34 days in castor oil.
This is probably part of why Estrannaise shows such a slow ramp-up and low values.
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