Post #2637934
2026-05-10 13:04 UTC
To do this, they wanted to make a chemical with two faces one that bound the quality control system and one that bound the protein they wanted to destroy. Both are difficult chemistries to build.
But the work on thalidomide revealed a ready made chemical that bound the quality control system, this spurred a whole ton of academic and biotech research that is just now bearing its first fruits.
5/🧵
Replies (1)
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@MCDuncanLab@mstdn.social 2026-05-10 13:10
What is so exciting about PROTACs is they can be designed to destroy almost protein, so their usefulness isn’t limited to cancer therapies, there are PROTACs in the works for neurodegenerative diseases and autoimmunity. It’s really an amazing time to be in bioscience (there’s bad stuff happening to the scientific enterprise esp in the US but I’ll leave this thread mainly positive) 🧵/end