Post #2637933
2026-05-10 12:59 UTC
And this is where it intersects with another line of research. In the early 2000s, Kathleen Sakamoto, Craig Crews and Ray Deshaies described the first attempt to hijack the cells quality control system to target a protein they chose.
The process worked in principle, but they needed to find a better way to bring the quality control system to the protein they wanted to destroy.
4/🧵
https://pmc.ncbi.nlm.nih.gov/articles/PMC37474/
Replies (1)
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@MCDuncanLab@mstdn.social 2026-05-10 13:04
To do this, they wanted to make a chemical with two faces one that bound the quality control system and one that bound the protein they wanted to destroy. Both are difficult chemistries to build. But the work on thalidomide revealed a ready made chemical that bound the quality control system, this spurred a whole ton of academic and biotech research that is just now bearing its first fruits. 5/🧵