Post #2637932
2026-05-10 12:50 UTC
The target was a protein known as cereblon. Cereblon is a protein that is part of the cell’s quality control system. It flags other proteins for destruction.
https://www.science.org/doi/10.1126/science.1177319 (Sorry paywalled)
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@MCDuncanLab@mstdn.social 2026-05-10 12:59
And this is where it intersects with another line of research. In the early 2000s, Kathleen Sakamoto, Craig Crews and Ray Deshaies described the first attempt to hijack the cells quality control system to target a protein they chose. The process worked in principle, but they needed to find a better way to bring the quality control system to the protein they wanted to destroy. 4/🧵 https://pmc.ncbi.nlm.nih.gov/articles/PMC37474/