Not really, no. The US is heavily gerrymandered and there's plenty of disenfranchisement to go around, but fundamentally Republicans don't control general elections the same way Democrats control their primaries, and centrist Democrats have many tools (rhetorical and otherwise) to get primary votes that Republicans don't in general elections. And, as I said, people don't vote in primaries. Besides, this theory has already been tested in practice; according to election polling Bernie would've absolutely trounced Trump in 2016, even though he lost the primary.