Post #4071599
2026-07-24 20:10 UTC
@BioMan@awful.systems
> even RNA with sequence statistics that are not quite like that of your species can set off an inflammatory reaction, immune system cells seeing RNA inside them that is overly compact and optimized like viral RNA treat them as sources of antigen rather than self
I was aware of the other DNA/RNA recognition/defense mechanisms, but not of the ones I quote from your toot, here.
May I kindly ask for some references/sources? I'm quite interested!
Replies (1)
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@BioMan@awful.systems 2026-07-25 04:58
I kind of read wayyyyy too many preprints and some of that is the result of super briefly summarizing some things I have read recently. Here: www.biorxiv.org/content/…/2024.11.26.625518v2 poor codon optimality for your translation system leads to immunogenicity and activation of innate immune signaling in animal cells As for length and super optimized proteins, it’s mostly about RIG proteins (see www.pnas.org/doi/10.1073/pnas.1005077107 for an old bit of a review) and the whole DRIP hypothesis about how short mismanufactured proteins are preferentially the source of presented antigens