Post #4079902

I kind of read wayyyyy too many preprints and some of that is the result of super briefly summarizing some things I have read recently. Here: www.biorxiv.org/content/…/2024.11.26.625518v2 poor codon optimality for your translation system leads to immunogenicity and activation of innate immune signaling in animal cells As for length and super optimized proteins, it’s mostly about RIG proteins (see www.pnas.org/doi/10.1073/pnas.1005077107 for an old bit of a review) and the whole DRIP hypothesis about how short mismanufactured proteins are preferentially the source of presented antigens