My desktop computer monitor is a 28 inch 4K screen, so yes, it is on the upper end of the median screen size, I guess. I ran Hyprland on my laptop (13 inch 1080p) for some time but I like my environment harmonized, so I use the same configuration there, too. For easier management I make use of labwc’s areas and snapping feature to have windows proportionally the same size on both screens. The areas use percentages by default, which makes it quite easy. I have top, bottom, left, and right, the four corner quarters and two different center regions. On my laptop I usually only use the center region for the browser.