Post #4149129
2026-07-27 22:45 UTC
Replies (2)
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@zvavybir@social.zvavybir.eu 2026-07-28 20:12
@michaela_p@toot.lgbt Not what you've asked, but do you have any idea why pills aren't doing anything (are you taking enough of them and of some anti-androgen?)? Because it might be good to investigate that first to see if you have something (e.g. intersexuality) going on that could complicate the easy default picture we in the DIY community usually prioritize. Alternatively to these injectables you could try estradiol stickies. They are a new, experimental administration route that makes the pills they are made out of multiple times as effective and should (in my very much non-expert understanding¹) have no risks outpacing those intrinsic to estradiol (but could provide you with a sufficiently high dosage if somehow you're body just is bad at responding to E). The authoritative source on them is somehow the following Neocities site: https://stickies.neocities.org/stickies (¹ I'm a mathematician, which is probably as far away from a doctor as possible…)
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@gwenthefops@transfem.social 2026-07-28 23:29
@michaela_p@toot.lgbt I'm a computer toucher, not in any pharmacological area but... I'm pretty sure that, unless there's a third compound on the injectable, this isn't gonna do shit either. Both, medroxyprogesterone and norethisterone enanthate are artifical progesterone compounds, so they will mimic the action of progesterone in the body (possibly with off-target activity, or more activity on some parts than others), but the crucial part is that neither of them is a form of estrogen, nor will they be metabolized by the body as estrogen. You'll essentially be taking HRT as only prog, no E. No bueno