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@pjacock@fediscience.org

Post #2630373

2026-02-06 11:30 UTC

@zerodivision@fediscience.org How exactly are the alignments defined? Simple offsets that apply to the entire feature (easy) or might potentially there be different shifts within a feature (within introns or worse exons)? For the easy case you might use Biopython (shifting locations by an offset is as simple as adding an integer), but would need some familiarity to setup the plumbings. Could probably handle shifting each exon too (sublocations) but more faff. Shifts in CDS meaning due to alignment gaps would be a right pain.

Replies (1)

  • @pjacock@fediscience.org Well yes, worst case I guess - with potential indels in CDS regions. That's why I'm very hesitant to write something from scratch / using biopython.

    Open ##2630374