Post #2475515
2026-04-11 22:06 UTC
@trendless@zeroes.ca Thank you for the link to the paper @Rhyothemis@zeroes.ca . Here's a quote from there that explains why they suspect the causality goes in this direction: "Persistent gut barrier dysfunction allows microbial-derived products such as lipopolysaccharides (LPS) and bacterial DNA to enter systemic circulation, driving chronic immune activation." 1/
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@david42@mastodon.online 2026-04-11 22:06
@trendless@zeroes.ca @Rhyothemis@zeroes.ca "This persistent immune stimulation promotes CD4+ T cell activation, facilitating maintenance and potential expansion of the HIV reservoir, which is predominantly harbored within the GALT. Additionally, microbial metabolites could in turn affect the kynurenine pathway, whose enzymatic activity has been associated with the size of the HIV reservoir." 2/