@supersciencegrl.co.uk@bsky.brid.gy
Post #1971886
2026-04-28 17:32 UTC
Propofol was the first substrate I used in dead school. To me it was just a starting material. I was surprised to learn it was a drug when I was looking up its metadata to calculate my stoichiometries!
Replies (1)
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@sellathechemist@mastodon.social 2026-04-28 19:52
@supersciencegrl.co.uk My astonishment with it was - and sorry to be dark here - to the fact that, at Auschwitz, prisoners would be injected with phenol directly into the heart. So the effect of the two isopropyl groups when you inject the stuff knocked me over (groan). And then to my amusement, I discovered that a neighbour of mine did the chemical biology required to identify the binding site on the GABAA receptor. It is an amazing molecule. https://www.nature.com/articles/nchembio.1340