Post #1409958

"Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation", Karadas et al. 2026 (Dima Rinberg's lab). https://www.nature.com/articles/s41593-026-02250-y Circuits in the mouse olfactory bulb implement a rapid filter: "Animals who rely on smell need to identify and discriminate odors despite fluctuations in concentration, yet odor receptor activation is strongly concentration dependent. [...] We found that the glomeruli [...] activated earliest in a sniff robustly represented odor identity across concentrations, ... . [via] a short temporal window of excitability at a sniff’s onset, followed by prolonged odor-evoked inhibition. The OB implements a rapid temporal filter, which is responsible for stabilizing identity across concentrations while decorrelating responses between odors." #neuroscience #olfaction #mouse